Influence of lipopolysaccharide on the development of oxidative-nitrosative stress in the liver of rats under conditions of chronic alcohol intoxication

Alcohol abuse is a common phenomenon among the countries of European continent. One first organs suffering from alcohol-induced damage liver. Activation Kupffer cells, as part mononuclear phagocyte system, plays significant role in development oxidative-nitrosative Systemic inflammatory response affects polarization macrophages throughout body and may affect alcohol hepatocytes. The aim this work to study effect vivo stimulation by S. typhi bacterial lipopolysaccharide on stress rat liver under conditions chronic intoxication. Male Wistar rats were randomly divided into 4 groups: I - control; II received 0.4 μg/kg typhi; III with induced alcoholic hepatitis, IV intoxication injected lipopolysaccharide. experiment lasted 63 days. We studied pro-oxidants antioxidant enzymes, concentration sulfide anion, nitric oxide production malonic dialdehyde tissues. In administration enhances ethanol-induced oxidative via increased superoxide anion despite adaptive increase activity enzymes. Nitric oxide, which increases during prolonged lipopolysaccharide, their combination, mainly metabolizes peroxynitrite